KRT9

(Keratin 9)

 

  • Alias                                 (According to NCBI)

 
  • EPPK 
  • K9 
  • keratin 9 (epidermolytic palmoplantar keratoderma)
  • Keratin, type I cytoskeletal 9 (Cytokeratin 9) (K9) (CK 9).
  • This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma.
  • Location: 17q21.1-q21.2
  • Orientation: minus strand
  • Size: 6215 bp
  • 8 exons
  • DNA sequence (Human): NC_000017. 

  •  

  • CGH (17q21.2):  Losses (%) -1.7  Gain (%)  7.8 
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human):NM_000226

  • Size:2287 bp

  • cDNA libraries:

  • Size: 622 amino acids; 61987 Da
  • Catalytic activity:

  • Subcellular location: intracellular,cytoplasm,cytoskeleton,intermed filament

  • Protein domains

 

                              
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)