LAMR1

(Laminin receptor 1)

 

  • Alias                                 (According to NCBI)

 
  • 37LRP
  • 67LR
  • LAMB2
  • RPSA
  • p40
  • 67kD, ribosomal protein SA
  • laminin receptor 1 (67kD)
  • laminin receptor 1 (67kD, ribosomal protein SA) 
  • laminin receptor 1 (ribosomal protein SA, 67kDa)
  • 40S ribosomal protein SA (p40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding
    protein) (NEM/1CHD4) (Multidrug resistance- associated protein MGr1-Ag).
  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Location: 3p21.3
    Orientation: plus strand
  • Size:5721 bp
  •  7 exons
  • DNA sequence (Human):  NC_000003

  • CGH (3p21.3):  Losses (%)  -29.1    Gain (%)  0.6     
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:294 amino acids; 32723 Da
  • Catalytic activity:
  • Subcellular location: Cytoplasmic.

  • Protein domains
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)