• Alias                                 (According to NCBI)

• FLJ26625,
• JTK8
• Yamaguchi sarcoma viral (v-yes-1) oncogene homolog;
• Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog

• Description   

  (According to SwissProt)

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 8q13
• Size: 130760 bp
• exons: 11
• DNA sequence (Human): NC_000008.9

• CGH (8q13):  Losses (%) -1.1   Gain (%)  25.7  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : LYN
• SNPs: 4067

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_002350.1 

• Size: 2298 bp

• cDNA libraries:

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 512 amino acids: 58574 Da
• Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

• Protein domains

• Protein sequence (Human): P07948

• Homologous genes:  55649

• 2D PAGE:

• 3D Structure:  

• PTM: LYN

• Pathways and interactions (According to BioCarta,Kegg, IntAct)

• Pathway:

   Kegg hsa04662  B cell receptor signaling pathway
 Kegg hsa04664  Fc epsilon RI signaling pathway
 Kegg hsa04730  Long-term depression
 Kegg hsa05120  Epithelial cell signaling in Helicobacter pylori infection

           BioCarta  Eph Kinases and ephrins support platelet aggregation

           BioCarta  Phosphoinositides and their downstream targets.                        

• Protein interactions: P07948

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): HPA001231

• Clinical                            (According to OMIM, PubMed)

• OMIM : 165120
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy