MAOB

Monoamine oxidase B

 

  • Alias                                 (According to NCBI)

 
  • MGC26382 
  • MAO, brain 
  • MAO, platelet 
  • adrenalin oxidase 
  • monoamine oxidase B 
  • tyramine oxidase
  • Amine oxidase [flavin-containing] B (EC 1.4.3.4) (Monoamine oxidase) (MAO-B).

  • The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.
  • Location: Xp11.23
  • Orientation: minus strand
  • Size:  115824 bp
  • 15 exons
  • DNA sequence (Human): NC_000023

  • CGH (Xp11.23): 
  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_000898

  • Size: 2566 bp

  • cDNA libraries: MAOB
  • Size: 519 amino acids; 58631 Da
  • Catalytic activity: RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).

  • Subcellular location: Mitochondrial outer membrane

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
 

  • Clinical                            (According to OMIM, PubMed)