MDM2

                                                                                               (Mouse double minute 2)

  • Alias                                 (According to NCBI)

 
  • hdm2
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)
  • mouse double minute 2, human homolog of; p53-binding protein
  • p53-binding protein MDM2
  • Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein)

  • This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an auto regulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
  •  Location:12q14.3-q15
  • Orientation: Plus strand
  •  Size: 32,343 bp
  • Exons: 11
  • DNA Sequence: NT_029419

  • CGH (12q14.3-15):  Losses (%) -2.2  Gain (%)  8.9             
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  •   Size: 491 amino acids; 55232 Da
  •  Catalytic activity:
  •   Subcellular location: Nuclear and Cytoplasmic. Expressed predominantly in the nucleoplasm.
  •   Protein domains:

                  

  • Pathways and interactions (According to BioCarta, DIP)
   
  • Clinical                            (According to OMIM, PubMed)