MKI67

                                                                        (Antigen identified by monoclonal antibody Ki-67)

Alias                                 (According to NCBI)	KIA Proliferation-related Ki-67 antigen  antigen identified by monoclonal antibody Ki-67 Antigen KI-67
Description    (According to SwissProt)	Expression of this antigen occurs preferentially during late G1,S,G2 and M phases of cell cycle, while in cells at G0 phase the antigen cannot be detected. It is required for maintaining cell proliferation.
Chromosomal location (According to NCBI, CGH: progenetix)	Location: 10q25-qter Orientation: Minus strand Size: 29.541 bases 15 Exons DNA Sequence: NT_008818 CGH (10q25):  Losses (%) -14.5  Gain (%)  2.2
Mutations and SNPs (According to HGMD and SNP)	HGMD: SNPs: MKI67
m-RNA                       (According to NCBI and CGAP)	m-RNA Sequence: NM_002417 Size: 12515 bp c-DNA Libraries: MKI67
Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)	Size:3256 amino acids; 358741 Da Sub cellular location: Nuclear. predominantly localized in the  G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in  nuclear matrix. In mitosis it is present on all chromosomes. Protein domains:                                                                Protein sequence: P46013 Homologous genes: MKI67 2D PAGE: 3D Structure: PTM: MKI67
Pathways and interactions (According to BioCarta, DIP)	Pathways: Interactions: 28132N
Tissue (According to GeneNote, PubMed, HPA)	Tissue expression: PubMed Reference Human Protein Atlas (HPA): HPA001164
Clinical                            (According to OMIM, PubMed)	OMIM: 176741 PubMed:    Early detection      Diagnosis         Prognosis        Therapy