MMP7

                                                                                            ( matrix metalloproteinase 7) 

  • Alias                                 (According to NCBI)

 
  • MMP-7 
  • MPSL1
  • PUMP-1 
  • PUMP1
  • matrin
  • matrix metalloproteinase 7 (matrilysin, uterine)
  • uterine matrilysin
  • Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

  •  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain.
  • Location:11q21-q22
  • Orientation: Minus strand
  • Size:10,239 bases
  • 6 Exons
  • DNA Sequence: NT_033899

  • CGH (11q21-22):  Losses (%) -15.6  Gain (%)  6.1 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

    
  •  Size:267 amino acids; 29677 Da
  •  Catalytic activity:
  •  Protein domains:

    

                               
  • Pathways and interactions (According to BioCarta, DIP)
 

  • Clinical                            (According to OMIM, PubMed)