MMP-10

                                                                                       (matrix metalloproteinase 10)      

  • Alias                                 (According to NCBI)

 
  • SL-2 
  • STMY2 
  • matrix metalloproteinase 10 (stromelysin 2)
  • stromelysin 2
  • transin 2
  • Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin.
  • Location:11q22.3
  • Orientation: Minus strand
  •  Size:10,113 bases
  •  10 Exons
  •  DNA Sequence: NT_033899

  • CGH (11q22.3):  Losses (%) -14.5  Gain (%)  8.4 

  • Mutations and SNPs (According to HGMD and SNP)
  
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:476 amino acids; 54151 Da
  • Catalytic activity:
  • Protein domains:

                   

                              
  • Pathways and interactions (According to BioCarta, DIP)
 

  • Clinical                            (According to OMIM, PubMed)