MMP11

                                                                                        (Matrix metalloproteinase 11)

  • Alias                                 (According to NCBI)

 
  • SL-3 
  • ST3
  • STMY3
  • matrix metalloproteinase 11 (stromelysin 3)
  • stromelysin 3
  • Stromelysin-3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-11) (MMP-11) (ST3) (SL-3)

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
  • Location:22q11.23
  • Orientation: Plus strand
  • Size: 11,466 bases
  • 8 Exons
  • DNA Sequence: NT_011520

  • CGH (22q11.23):  Losses (%) -1.1  Gain (%)  15.1 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 488 amino acids; 54595 Da
  • Protein domains:

               

                                     

  • Protein sequence: P24347
  • Homologous genes: MMP11
  • 2D PAGE:
  • 3D Strucutre:
  • PTM: MMP11
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)