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Alias (According to NCBI)
- MMP-X1
- MT1-MMP
- MTMMP1
- matrix metalloproteinase 14 (membrane-inserted)
- membrane-type matrix metalloproteinase 1
- membrane-type-1 matrix metalloproteinase
- Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).
Description
(According to SwissProt)
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location:14q11-q12
- Orientation: Plus strand
- Size:11,009 bases
- 11 Exons
- DNA Sequence: NT_026437
CGH (14q11-12): Losses (%) -0.0 Gain (%) 4.5
- HGMD:
- SNPs: MMP14
- Size:582 amino acids; 65883 Da
- Catalytic activity:
- Subcellular location: Type I membrane protein (Potential)
- Protein domains:
- Pathways: Inhibition of Matrix Metalloproteinases
- Interactions:
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): MMP14
- OMIM:600754
- PubMed: Early detection Diagnosis Prognosis Therapy