MMP3

                                                                                    (Matrix metalloproteinase 3)

  • Alias                                 (According to NCBI)

 
  • SL-1
  • STMY
  • STMY1 
  • STR1
  • TRANSIN 
  • progelatinase 
  • proteoglycanase 
  • transin-1
  • matrix metalloproteinase 3 (stromelysin 1, progelatinase)
  • Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1)

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
  • Location:11q22.3
  • Orientation: Minus strand
  • Size: 53,689 bases
  • 10 Exons
  • DNA Sequence: NT_033899

  • CGH (11q22.3):  Losses (%) -14.5  Gain (%)  8.4 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 477 amino acids; 53977 Da
  • Catalytic activity: Preferential cleavage where P1', P2' and P3' are hydrophobic residues
  • Protein domains:

                 

                                    
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)