MUC1

                                                                               (Mucin 1, transmembrane)

  • Alias                                 (According to NCBI)

 
  • CD227 
  • EMA 
  • PEM 
  • PUM
  • episialin
  • DF3 antigen
  • H23 antigen
  • epithelial membrane antigen
  • mucin 1, transmembrane
  • peanut-reactive urinary mucin
  • polymorphic epithelial mucin
  • Mucin 1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen)

  • CD227 (MUC1)is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of CD227 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O-glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
  • Location:1q21
  • Orientation: Minus strand
  • Size:4,260 bases
  • 8 Exons
  • DNA Sequence: NT_079484

  • CGH (1q21):  Losses (%) -1.1  Gain (%)  7.8 

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:1255 amino acids; 122072 Da
  • Catalytic activity:
  • Sub cellular location: Type I membrane protein. Two secreted forms are also produced.
  • Protein domains:

                   

                                       

  • Protein sequence: P15941
  • Homologous genes: MUC1
  • 2D PAGE:
  • 3D STructure:
  • PTM: MUC1
  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)