NDRG1

N-myc downstream regulated gene 1

 

  • Alias                                 (According to NCBI)

 
  • CAP43
  • CMT4D 
  • DRG1
  • GC4
  • HMSNL
  • NDR1
  • NMSL
  • PROXY1 
  • RIT42 
  • RTP
  • TARG1 
  • TDD5 
  • Human mRNA for RTP, complete cds 
  • N-myc downstream regulated 
  • N-myc downstream regulated gene 1
  • N-myc downstream regulated gene 1 protein 
  • differentiation-related gene 1 protein 
  • nickel-specific induction protein Cap43 
  • protein regulated by oxygen-1
  • reducing agents and tunicamycin-responsive protein
  • NDRG1 protein (N-myc downstream regulated gene 1 protein) (Differentiation-related gene 1 protein)
    (DRG1) (Reducing agents and tunicamycin-responsive protein) (RTP) (Nickel-specific induction
    protein Cap43) (Rit42).

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom.
  • Location: 8q24.3
  • Orientation: minus strand
  • Size: 60,415 bp
  • 16  exons
  • DNA sequence (Human): NC_000008

  • CGH (8q24.3):  Losses (%) -0.0   Gain (%)  39.1  

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 394 amino acids; 42835 Da
  • Catalytic activity:

  • Subcellular location: Whereas in prostate epithelium and placental chorion it is located in both the cytoplasm and the nucleus, nuclear staining is not observed in colon epithelium cells. Instead its localization changes from the cytoplasm to the plasma membrane during differentiation of colon carcinoma cell lines in vitro.

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
 

 
  • Clinical                            (According to OMIM, PubMed)