• Alias                                 (According to NCBI)

• NRF2
• nuclear factor (erythroid-derived 2)-like 2
• Nuclear factor erythroid 2 related factor 2 (NF-E2 related factor 2) (NFE2-related factor 2)
  (Nuclear factor, erythroid derived 2, like 2) (HEBP1).

• Description   

  (According to SwissProt)

• NFE2 (MIM 601490), NFE2L1 (MIM 163260), and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors. They share highly conserved regions that are distinct from other bZIP families, such as JUN (MIM 165160) and FOS (MIM 164810), although remaining regions have diverged considerably from each other (Chan et al., 1995).

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 2q31
• Orientation: minus  strand
• Size: 34379 bp
•  5 exons
• DNA sequence (Human): NC_000002 

• CGH (2q31):  Losses (%) -5.6   Gain (%)  7.8  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD (Human Gene Mutation Database):
• SNPs: NFE2L2

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_006164

• Size: 2439 bp

• cDNA libraries: NFE2L2

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 605 amino acids; 67826 Da
• Catalytic activity:

• Subcellular location: Nuclear (By similarity).
  Protein domains

• Protein sequence (Human): Q16236

• Homologous genes:NFE2L2

• 2D PAGE:Q16236

• 3D Structure:

• PTM: NFE2L2

• Pathways and interactions (According to BioCarta, DIP)

• Pathway:

          Oxidative Stress Induced Gene Expression Via Nrf2

• Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): HPA002990

• Clinical                            (According to OMIM, PubMed)

• OMIM: 600492

• PubMed:    Early detection      Diagnosis         Prognosis        Therapy