NOS II                                         

                                                    (Nitric Oxide Synthase Type II)

  • Alias                                 (According to NCBI)

 
  • HEP-NOS 2
  • INOS 2
  • NOS2 2
  • NOS, type II 2
  • nitric oxide synthase 2A (inducible, hepatocytes) 1, 2, 5
  • nitric oxide synthase, macrophage 2
  • Nitric oxide synthase, inducible (EC 1.14.13.39) (NOS, type II) (Inducible NOS) (iNOS) (Hepatocyte NOS) (HEP-NOS). 3

  • Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

  • Location: 17q11.2-q12   
  • Orientation: minus strand
  • Size: 43,762 bases
  • Exons: 27 
  • DNA sequence (Human): NC_000017

 

  • CGH (17q11.2):  Losses (%) - 1.7   Gain (%)  7.8  

  • Mutations and SNPs (According to HGMD and SNP)

  • m-RNA                       (According to NCBI and CGAP)

 

  • Size: 1153 amino acids; 131117 Da
  • Catalytic activity: L-arginine + n NADPH + m O(2) = citrulline + nitric oxide + n NADP(+).

·         Subcellular location:

·         Protein domains

        

·         Protein sequence (Human): P35228

·         Homologous genes: NOS2

·         2D PAGE: P35228

·         3D Structure: 1NSI (3D), 2NSI (3D), 4NOS (3D) 

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

1.      NO2-dependent IL 12 Pathway in NK cells

 

2.      Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

 

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)