NPM1

Nucleophosmin (nucleolar phosphoprotein B23, numatrin)

 

  • Alias                                 (According to NCBI)

 
  • B23 
  • NPM
  • numatrin 
  • nucleolar phosphoprotein B23 
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • nucleophosmin/nucleoplasmin family, member 1 
  • Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin) (Nucleolar protein NO38).

  • Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome.
  • Location: 5q35
  • Orientation: plus strand
  • Size: 23,768 bp
  • 11 exons
  • DNA sequence (Human):  NC_000005


  • CGH (5q35):  Losses (%) - 13.4   Gain (%)  2.8  

  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 294 amino acids; 32575 Da
  • Catalytic activity:
  • Subcellular location: Nuclear. Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs.

  • Protein domains


 

  • Protein sequence (Human): P06748

  • Homologous genes:

  • 2D PAGE: P06748

  • 3D Structure:

  • PTM: NPM1
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 

  • Clinical                            (According to OMIM, PubMed)