NPR3

Natriuretic peptide receptor C/guanylate cyclase C

 

  • Alias                                 (According to NCBI)

 
  • ANPRC
  • natriuretic peptide receptor C
  • natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
  • Atrial natriuretic peptide clearance receptor precursor (ANP-C) (ANPRC) (NPR-C) (Atrial
    natriuretic peptide C-type receptor).

  • The family of natriuretic peptides (see MIM 108780) elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.
  • Location: 5p14-p13
  • Orientation: plus strand
  • Size: 75,591 bp
  • 8 exons
  • DNA sequence (Human): NC_000005

  • CGH (5p14-13):  Losses (%) - 3.4   Gain (%)  16.2  

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_000908

  • Size: 2651 bp

  • cDNA libraries: NPR3
  • Size:541 amino acids; 59807 Da
  • Catalytic activity:

  • Subcellular location: Type I membrane protein.

  • Protein domains

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
 

 
  • Clinical                            (According to OMIM, PubMed)