• Alias                                 (According to NCBI)

• ARIA 
• GGF 
• GGF2
• HGL 
• HRG 
• HRGA 
• NDF 
• SMDF 
• glial growth factor 
• heregulin, alpha (45kD, ERBB2 p185-activator) 
• neu differentiation factor 
• neuregulin 1
• sensory and motor neuron derived factor 
• Neuregulin-1, sensory and motor neuron-derived factor isoform.
• Pro-neuregulin-1 precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor)
  (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor inducing
  activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

• Description   

  (According to SwissProt)

• Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location:8p12
• Orientation: plus strand
• Size: 216321 bp
• 3 exons
• DNA sequence (Human): NC_000008.

• CGH (8p12):  Losses (%) - 12.8   Gain (%)  6.7  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD :
• SNPs: NRG1

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_004495 , NM_013956 , NM_013957, NM_013958, NM_013959, NM_013960, NM_013961 , NM_013962 , NM_013964, 

• Size: 1651 bp   , 2199 bp , 2490 bp ,  1715 bp , 1860 bp , 1793 bp , 1199 bp  , 1986 bp  , 2224 bp

• cDNA libraries: NRG1

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 296 amino acids; 31685 Da
• Catalytic activity:

• Subcellular location: Secreted. May possess an internal uncleaved signal sequence.

• Protein domains

•       

• Protein sequence (Human): Q15491

• Homologous genes: NRG1

• 2D PAGE : Q15491

• 3D Structure: 1HAE

• PTM: NRG1

• Pathways and interactions (According to BioCarta, DIP)

• Pathway:

           Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling                 

• Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB002304

• Clinical                            (According to OMIM, PubMed)

• OMIM: 142445

• PubMed:    Early detection      Diagnosis         Prognosis        Therapy