p15/ CDKN2B

                                                                                (cyclin-dependent kinase inhibitor 2B) 

  • Alias                                 (According to NCBI)

 

  
  • INK4B
  • MTS2
  • P15
  • TP15
  • p14_INK4B
  • p15_INK4B 
  • CDK inhibitory protein 
  • CDK4B inhibitor
  • cyclin-dependent kinase 4 inhibitor B
  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
  • cyclin-dependent kinases 4 and 6 binding protein
  • multiple tumor suppressor 2
  • p14_CDK inhibitor
  • p15 CDK inhibitor
  • Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (Multiple tumor suppressor 2) (MTS2).
  •  This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
  •  Location:9p21.3
  • Orientation: Minus strand
  • Size: 5,037 bases
  • 2 Exons
  • DNA sequence:NT_008413

                     

          

  • CGH (9p21.3):  Losses (%) - 30.7   Gain (%)  7.3  
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:138 amino acids; 14722 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains:

                                           

                            

  • Pathways and interactions (According to BioCarta, DIP)
  
  • Clinical                            (According to OMIM, PubMed)