P21/ CDKN1A

(cyclin-dependent kinase inhibitor 1A)

 

  • Alias                                 (According to NCBI)

 
  • P21
  • CDKN1A (cyclin-dependent kinase inhibitor 1A)
  • WAF1(Wild-type activated fragment 1)
  • CIP1(CDK interacting protein 1)
  • MDA6 (Melanoma differentiation associated protein 6)
  • SDI1(Senescence cell- derived inhibitor-1)
  • CAP20
  • May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. May bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.

  • Location: 6p21.2

  • Orientation: plus strand

  • Size: 8622 bases

  • 3 exons

  • DNA sequence (Human): NT_007592

     

 

         

         

  • CGH (6p21.2):  Losses (%) - 1.1   Gain (%)  9.5  

 
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • mRNA sequence (Human): Transcript variants (internal sequence segment in the 5' UTR region) 1) NM_000389 2) NM_078467
  • Size: 164 amino acids, 18 kDa
  • Subcellular location: Nuclear
  • Tissue specificity: Expressed in all adult human tissues, with 5-fold lower levels observed in the brain

  • Protein domains:

                     

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)