• Alias                                 (According to NCBI)

• CDKN4
• KIP1
• P27KIP1
• cyclin-dependent kinase inhibitor 1B (p27, Kip1)
• cyclin-dependent kinase inhibitor 1B (p27, Kip1) 
• Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1).

• Description   

  (According to SwissProt)

• The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Therefore  involved in  G1 arrest. It is under expressed in the development and
  progression of oral squamous cell carcinoma

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location:12p13.2
• Orientation: Plus strand
• Size:4,993 bases
• 3 Exons
• DNA Sequence:NT_009714

• CGH (12p13.2):  Losses (%) - 8.9   Gain (%)  3.9  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : CDKN1B

• SNPs: CDKN1B

• m-RNA                       (According to NCBI and CGAP)

• m-RNA Sequence:NM_004064
• Size:2422 bp
• c DNA libraries: p27

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size:198 amino acids; 22073 Da
• Catalytic activity:
• Sub cellular location: Nucleus
• Protein domains:

• Protein sequence:P46527
• Homologous genes: p27
• 2D PAGE:
• 3D structure: 1JSU
• PTM: p27

• Pathways and interactions (According to BioCarta, DIP)

• Pathways: Cell Cycle: G1/S Check Point
• Cyclins and Cell Cycle Regulation
• Down regulated of MTA-3 in ER-negative Breast Tumors
• Influence of Ras and Rho proteins on G1 to S Transition
• p38 MAPK Signaling Pathway
• PTEN dependent cell cycle arrest and apoptosis
• Regulation of p27 Phosphorylation during Cell Cycle Progression
• Stress Induction of HSP Regulation

Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB003691

• Clinical                            (According to OMIM, PubMed)

• OMIM:600778
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy