P34/CDC2

(Cell Division Cycle 2)

 

  • Alias                                 (According to NCBI)

 
  • CDK1 
  • cell cycle controller CDC2 
  • cell division control protein 2 homolog 
  • cell division cycle 2, G1 to S and G2 to M 
  • cyclin-dependent kinase 1 
  • p34 protein kinase 
  • Cell division control protein 2 homolog (EC 2.7.1.37) (p34 protein kinase) (Cyclin-dependent
    kinase 1) (CDK1).
  • The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
  • Location: 10q21.1
  • Orientation: plus strand
  • Size: 15689 bp
  • 8 exons
  • DNA sequence (Human): NC_000010.

  • CGH (10q21.1):  Losses (%) - 11.7   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 297 amino acids; 34095 Da
  • Catalytic activity: ATP + a protein = ADP + a phosphoprotein

  • Subcellular location: Nuclear

  • Protein domains

                                   
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: 35N
  • Clinical                            (According to OMIM, PubMed)