Alias (According to NCBI)
- TRP53
- p53
- Tumor protein p53 (Li-Fraumeni syndrome)
- Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13)
Description
(According to SwissProt)
It acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- location: 17p13.1
- Orientation: minus strand
- Size: 19,178 bp
- 11 Exons
- DNA sequence: NT_010718
CGH (17p13.1): Losses (%) - 5.0 Gain (%) 10.1
- Size: 393 amino acids; 43653 Da
- Catalytic activity:
- Sub cellular location: Cytoplasmic and nuclear
- Protein domains:
- Apoptotic Signaling in Response to DNA Damage.
- ATM Signaling Pathway.
- Cell Cycle: G1/S Check Point
- Cell Cycle: G2/M Checkpoint.
- Chaperones modulate interferon Signaling Pathway
- Double Stranded RNA Induced Gene Expression
- HIV-I Nef: negative effector of Fas and TNF.
- Hypoxia and p53 in the cardiovascular system
- Overview of telomerase protein component gene hTert Transcriptional Regulation.
- p53 Signaling Pathway.
- RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
- Regulation of cell cycle progression by Plk3
- Regulation of transcriptional activity by PML
- Rho cell motility signaling pathway.
- Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility.
- Telomeres, Telomerase, Cellular Aging, and Immortality
- Tumor Suppressor Arf Inhibits Ribosomal Biogenesis.
- Interactions: P04637
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA): CAB002973
- OMIM: 191170
- PubMed: Early detection Diagnosis Prognosis Therapy