PCNA

                                                                                     (Proliferating cell nuclear antigen)

  • Alias                                 (According to NCBI)

 
  • MGC8367
  • cyclin
  • DNA polymerase delta auxiliary protein
  • proliferating cell nuclear antigen
  • Proliferating cell nuclear antigen (PCNA) (Cyclin)

  • The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene.
  • Location:20pter-p12
  • Orientation: Minus strand
  • Size:11,669 bases
  • 7 Exons
  • DNA Sequence: NT_011387

  • CGH (20p12):  Losses (%) - 2.8   Gain (%)  17.9  
  • Mutations and SNPs (According to HGMD and SNP)
  • HGMD :  

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 261 amino acids; 28768 Da
  • Catalytic activity:
  • Sub cellular location: Nuclear
  • Protein domains:

                                               
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)