PDGFA

                                                                (Platelet-derived growth factor, A chain precursor) 

  • Alias                                 (According to NCBI)

 
  • PDGF1
  • PDGF A-chain
  • platelet-derived growth factor alpha polypeptide
  • Platelet-derived growth factor, A chain precursor (PDGF A-chain) (Platelet-derived growth factor alpha polypeptide)(PDGF-1).

  • The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth.
  • Location:7p22
  • Orientation: Minus strand
  • Size:22,039 bases
  • 3 Exons
  • DNA Sequence: NT_079516

  • CGH (7p22):  Losses (%) - 0.6   Gain (%)  11.7  

 
  • Mutations and SNPs (According to HGMD and SNP)
  • SNPs:
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size:211 amino acids; 24043 Da
  • Catalytic activity:
  • Sub cellular location:
  • Protein domains:

                              
  • Pathways and interactions (According to BioCarta, DIP)
  

  • Clinical                            (According to OMIM, PubMed)