PHB

(Prohibitin)

 

  • Alias                                 (According to NCBI)

 
  • prohibitin
  • breast cancer, sporadic
  • Prohibitin.
  •  Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.
  • Location: 17q21
  • Orientation: minus  strand
  • Size: 10823 bp
  •  7 exons
  • DNA sequence (Human): NC_000017

  • CGH (17q21):  Losses (%) - 1.7   Gain (%)  7.8  

  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_002634

  • Size: 1826 bp

  • cDNA libraries: PHB
  • Size: 272 amino acids; 29804 Da
  • Catalytic activity:

  • Subcellular location: Cytoplasmic.

  • Protein domains

                               
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions: 24248N
  • Clinical                            (According to OMIM, PubMed)