• Alias                                 (According to NCBI)

• UPA 
• URK
• U-plasminogen activator
• plasminogen activator, urinary
• plasminogen activator, urokinase
• urokinase-type plasminogen activator precursor 
• Urokinase-type plasminogen activator precursor (EC 3.4.21.73) (uPA) (U-plasminogen activator).

• Description   

  (According to SwissProt)

• This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer disease and also with decreased affinity for fibrin-binding. The protein encoded by this gene converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. This gene's proprotein is cleaved at a Lys-Ile bond by plasmin to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 10q24
• Orientation: plus strand
• Size:  6318 bp
• 10 exons
• DNA sequence (Human): NC_000010

• CGH (10q24):  Losses (%) - 9.5   Gain (%)  1.7  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD:
• SNPs: PLAU

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human): NM_002658

• Size:  2360 bp

• cDNA libraries: PLAU

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 431 amino acids; 48525 Da
• Catalytic activity: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

• Subcellular location:

• Protein domains

• Protein sequence (Human): P00749

• Homologous genes: PLAU

• 2D PAGE: P00749

• 3D Structure:1C5W

• PTM: PLAU

• Pathways and interactions (According to BioCarta, DIP)

• Pathway:

          Fibrinolysis Pathway

• Protein interactions: 137N

• Tissue

  (According to GeneNote, PubMed, HPA)

 

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): HPA008719

• Clinical                            (According to OMIM, PubMed)

• OMIM:

• PubMed:    Early detection      Diagnosis         Prognosis        Therapy