PPP1R3C

Protein Phosphatase 1

 

  • Alias                                 (According to NCBI)

 
  • PPP1R5
  • Phosphatase 1, regulatory inhibitor subunit 5 
  • protein phosphatase 1, regulatory (inhibitor) subunit 3C 
  • protein phosphatase 1, regulatory (inhibitor) subunit 5 
  • Phosphatase binding 1 protein PTG

  • Protein phosphatase-1 (PP1; see MIM 176875) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits PPP1R3 (MIM 600917) and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8; MIM 602636).
  • Location: 10q23-q24
  • Orientation: minus strand
  • Size: 4,659 bp
  • 2 exons
  • DNA sequence (Human): NC_000010


  • CGH (10q23 - 24):  Losses (%) - 7.8   Gain (%)  2.2  

  • Mutations and SNPs (According to HGMD and SNP)

 
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 316 amino acids; 36124 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

  • Protein sequence (Human): Q8TDR5

  • Homologous genes: PPP1R3C

  • 2D PAGE: Q8TDR5

  • 3D Structure:

  • PTM:

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)