PRDX4

Thioredoxin Peroxidase

 

  • Alias                                 (According to NCBI)

 
  • AOE37-2
  • AOE372
  • peroxiredoxin 4
  • thioredoxin peroxidase (antioxidant enzyme)
  • Peroxiredoxin 4 (EC 1.11.1.-) (Prx-IV) (Thioredoxin peroxidase AO372) (Thioredoxin-dependent
    peroxide reductase A0372) (Antioxidant enzyme AOE372) (AOE37-2).

  • The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.
  • Location: xp22.11
  • Orientation: plus strand
  • Size: 18870 bp
  • 7  exons
  • DNA sequence (Human): NC_000023

  • CGH (Xp22.11): 
  • Mutations and SNPs (According to HGMD and SNP)
  • m-RNA                       (According to NCBI and CGAP)

 
  • Size: 271 amino acids; 30540 Da
  • Catalytic activity: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

  • Subcellular location: Cytoplasmic.

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

 
  • Clinical                            (According to OMIM, PubMed)