SKP2

                                                                                (S-phase kinase-associated protein 2)

  • Alias                                 (According to NCBI)

 
  • FBL1
  • FBXL1
  • FLB1
  • MGC1366
  • CDK2/cyclin A-associated protein p45
  • S-phase kinase-associated protein 2 (p45)
  • S-phase kinase-associated protein 2 (F-box protein Skp2) (Cyclin A/CDK2-associated protein p45)
    (p45skp2)

  • This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas.
  • Location:5p13
  • Orientation: Plus strand
  • Size: 31,958 bases
  • 10 Exons
  • DNA Sequence: NT_006576

  • CGH (5p13): Losses (%) -5.6   Gain (%)  12.8  
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 424 amino acids, 47760 Da
  • Catalytic activity:
  • Subcellular location:
  • Protein domains:

                                                    
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)