SLC39A8

Solute carrier family 39 (zinc transporter)

 

  • Alias                                 (According to NCBI)

 
  • BIGM103 
  • LZT-Hs6 
  • solute carrier family 39 (metal ion transporter), member 8
  • solute carrier family 39 (zinc transporter), member 8
  • up-regulated by BCG-CWS
  • SLC39A8 protein (Fragment)
  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A8 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003)
  • Location: 4q22-q24
  • Orientation: minus strand
  • Size: 83476 bp
  • 8 exons
  • DNA sequence (Human):  NC_000004.

  • CGH (4q22 - 24): Losses (%) -18.4   Gain (%)  2.2  
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Protein                                  (According to SwissProt, Swiss2D, PDB)
  • Size: 97 amino acids; 10694 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

                                

  • Protein sequence (Human): Q9BVC0

  • Homologous genes: SLC39A8

  • 2D PAGE: Q9BVC0

  • 3D Structure:

  • PTM:
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)