Stat3

                                         (Signal transducer and activator of transcription 3)

  • Alias                                 (According to NCBI)

 
  • APRF
  • DNA-binding protein APRF
  • acute-phase response factor
  • signal transducer and activator of transcription 3 (acute-phase response factor)
  • Signal transducer and activator of transcription 3 (Acute-phase response factor).

  • This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.
  • Location:17q21
  • Orientation: Minus strand
  • Size:73,623 bases
  • 24 Exons
  • DNA Sequence: NT_010755

                  

  • CGH (17q21): Losses (%) -1.7   Gain (%)  7.8                 

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:770 amino acids; 88052 Da
  • Catalytic activity:

  • Subcellular location:

  • Protein domains:

                                       

  • Sub cellular location: Nuclear; translocated into the nucleus in response to phosphorylation.
  • Protein sequence:P40763
  • Homologous genes: STAT3
  • 3D Structure: 1BG1
  • PTM: STAT3

 
  • Pathways and interactions (According to BioCarta, DIP)
         
  • Clinical                            (According to OMIM, PubMed)