STAT5B

                                                                   (Signal transducer and activator of transcription 5B)

  • Alias                                 (According to NCBI)

 
  • STAT5
  • signal transducer and activator of transcription 5B
  • transcription factor STAT5B
  • Signal transducer and activator of transcription 5B

  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
  • Location: 17q11.2
  • Orientation: Minus strand
  • Size: 77,285 bases
  • 19 Exons
  • DNA Sequence: NT_010755

  • CGH (17q11.2): Losses (%) -1.7   Gain (%)  7.8  
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:787 amino acids,89865 Da
  • Catalytic activity:
  • Sub cellular location: Nuclear; translocated into the nucleus in response to phosphorylation
  • Protein domains:

                                                            
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)