TAL1

T-cell acute lymphocytic leukemia 1

 

  • Alias                                 (According to NCBI)

 
  • SCL
  • TCL5
  • T-cell acute lymphocytic leukemia 1
  • T-cell acute lymphocytic leukemia 1 (NOTE: redefinition of symbol)
  • T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell
    leukemia/lymphoma-5 protein).

  • Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. Binds to the LIM domain containing protein Rhombotin-2.
  • Location: 1p32
  • Orientation: minus strand
  • Size: 13480 bp
  • 4 exons
  • DNA sequence (Human): NC_000001


  • CGH (1p32): Losses (%) -3.4   Gain (%)  2.2  

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_003189

  • Size:5000 bp

  • cDNA libraries: TAL1
  • Size: 331 amino acids; 34270 Da  
  • Catalytic activity:

  • Subcellular location:

  • Protein domains

  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)