Alias (According to NCBI)
- transforming growth factor, alpha
- Transforming growth factor alpha precursor (TGF-alpha) (EGF-like TGF) (ETGF) (TGF type 1).
Description
(According to SwissProt)
Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor and competes with EGF for binding to the EGF receptor , stimulating its phosphorylation and producing a mitogenic response
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location: 2p13
- Orientation: Minus strand
- Size: 106,511 bases
- 6 Exons
- DNA Sequence: NT_022184
- CGH (2p13): Losses (%) -2.2 Gain (%) 5.0
- HGMD:
- SNP: TGFA
- Size:160 amino acids; 17006 Da
- Catalytic activity:
- Sub cellular location: Type I membrane protein (precursor form); extracellular (mature form).
- Protein domains:
- Pathways:
- ALK in cardiac myocytes
- Cell Cycle: G1/S Check Point
- Cytokines and Inflammatory Response
- Erythrocyte Differentiation Pathway
- Function of SLRP in Bone: An Integrated View
- MAPKinase Signaling Pathway
- NFkB activation by Nontypeable Hemophilus influenzae
- p38 MAPK Signaling Pathway
- Role of Tob in T-cell activation
- Selective expression of chemokine receptors during T-cell polarization
- Signal transduction through IL1R
- TGF beta signaling pathway
- Interactions: 5764N
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA) : TGFA
- OMIM:190170
- PubMed: Early detection Diagnosis Prognosis Therapy