Alias (According to NCBI)
- CED
- DPD1
- HGNC:2997
- TGFB
- diaphyseal dysplasia 1, progressive
- diaphyseal dysplasia 1, progressive (Camurati-Engelmann disease)
- transforming growth factor, beta 1
- transforming growth factor, beta 1 (Camurati-Engelmann disease)
- Transforming growth factor beta 1 precursor (TGF-beta 1).
Description
(According to SwissProt)
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide.
- Chromosomal location
(According to NCBI, CGH: progenetix)
- Location:19q13.1
- Orientation: Minus strand
- Size:23,560 bases
- 7 Exons
- DNA Sequence: NT_011109
CGH (19q13.1): Losses (%) -2.8 Gain (%) 8.9
- Size:390 amino acids; 44341 Da
- Catalytic activity:
- Sub cellular location: Secreted
- Protein domains:
- Pathways: ALK in cardiac myocytes
- Cell Cycle: G1/S Check Point
- Cytokines and Inflammatory Response
- Erythrocyte Differentiation Pathway
- Function of SLRP in Bone: An Integrated View
- MAPKinase Signaling Pathway
- NFkB activation by Nontypeable Hemophilus influenzae
- p38 MAPK Signaling Pathway
- Role of Tob in T-cell activation
- Selective expression of chemokine receptors during T-cell polarization
- Signal transduction through IL1R
- TGF beta signaling pathway
- Interactions: 5934N
- Tissue expression: PubMed Reference
- Human Protein Atlas (HPA) : CAB000361
- OMIM: 190180
- PubMed: Early detection Diagnosis Prognosis Therapy