TIMP1

                                                                             (Tissue inhibitor of metalloproteinase 1)

  • Alias                                 (According to NCBI)

 
  • CLGI
  • EPA
  • EPO 
  • HCI
  • TIMP
  • Erythroid-potentiating activity (tissue inhibitor of metalloproteinases)
  • erythroid potentiating activity
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
  • Metalloproteinase inhibitor 1 precursor (TIMP-1) (Erythroid potentiating activity) (EPA) (Tissue
    inhibitor of metalloproteinases) (Fibroblast collagenase inhibitor) (Collagenase inhibitor)

  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. This gene located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 is highly inducible at the transcriptional level in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females.
  • Location: XP11.3-P11.23
  • Orientation: Plus strand
  • Size: 30,413 bases
  • 6 Exons
  • DNA Sequence: NT_011568

  • CGH (Xp11.3 - 11.23): Losses (%)       Gain (%) 
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:207 amino acids,23171 Da
  • Catalytic activity:
  • Sub cellular location: Secreted
  • Protein domains:

                             

  • Protein sequence: P01033
  • 3D Structure: 1D2B
  • 2D PAGE:
  • 3D Structure:
  • PTM: TIMP1
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)