TIMP2

                                                                              (Tissue inhibitor of metalloproteinase 2)

  • Alias                                 (According to NCBI)

 
  • tissue inhibitor of metalloproteinase 2
  • Metalloproteinase inhibitor 2 precursor (TIMP-2) (Tissue inhibitor of metalloproteinases-2)
    (CSC-21K)

  • This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. Unlike the inducible expression of some other TIMP gene family members, the expression of this gene is largely constitutive. In addition, this gene diplays several features of a housekeeping gene and is likely to play a role significantly different from that of other family members.
  • Location:17q25
  • Orientation: Minus strand
  • Size:72,401 bases
  • 5 Exons
  • DNA Sequence: NT_010641

  • CGH (17q25): Losses (%) -1.7   Gain (%)  11.2  

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:220 amino acids,24,399 Da
  • Catalytic activity:
  • Sub cellular location: Secreted
  • Protein domains:

                                            
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)