TNFRSF10A

                                                        (Tumor necrosis factor receptor superfamily, member 10a)

  • Alias                                 (According to NCBI)

 
  • APO2
  • DR4
  • MGC9365
  • TRAILR-1
  • TRAILR1
  • TNF-related apoptosis inducing ligand receptor 1
  • cytotoxic TRAIL receptor
  • cytotoxic ligand TRAIL receptor
  • death receptor 4
  • tumor necrosis factor receptor superfamily, member 10a
  • Tumor necrosis factor receptor superfamily member 10A precursor (Death receptor 4) (TNF-related
    apoptosis-inducing ligand receptor 1) (TRAIL receptor-1) (TRAIL-R1)

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
  • Location:8p21
  • Orientation: Minus strand
  • Size :33,669 bases
  • 10 Exons
  • DNA Sequence: NT_023666

  • CGH (8p21): Losses (%) -28.5   Gain (%)  3.9 

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 468 amino acids; 50061 Da
  • Catalytic activity:
  • Sub cellular location: Type I membrane protein
  • Protein domains:

                                        
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)