TNFRSF10B

                                                      (Tumor necrosis factor receptor superfamily, member 10b)

  • Alias                                 (According to NCBI)

 
  • DR5
  • KILLER
  • KILLER/DR5
  • TRAIL-R2 
  • TRAILR2
  • TRANCE-R
  • TRICK2
  • TRICK2A
  • TRICK2B 
  • TRICKB
  • ZTNFR9 
  • Fas-like protein precursor
  • TNF-related apoptosis-inducing ligand receptor 2
  • TRAIL receptor 2 
  • Weakly similar to cytotoxic ligand TRAIL receptor [H.sapiens]
  • apoptosis inducing protein TRICK2A/2B
  • apoptosis inducing receptor TRAIL-R2
  • cytotoxic TRAIL receptor-2
  • death domain containing receptor for TRAIL/Apo-2L
  • death receptor 5
  • p53-regulated DNA damage-inducible cell death receptor (killer)
  • tumor necrosis factor receptor superfamily, member 10b
  • tumor necrosis factor receptor-like protein ZTNFR9
  • Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (TNF-related
    apoptosis-inducing ligand receptor 2) (TRAIL receptor-2) (TRAIL-R2)

  • The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracelluar death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
  • Location: 8p22-p21
  • Orientation: Minus strand
  • Size: 49,046 bases
  • 9 Exons
  • DNA Sequence: NT_023666

  • CGH (8p22-p21): Losses (%) -35.8   Gain (%)  3.9 

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 440 amino acids; 47850 Da
  • Catalytic activity:
  • Sub cellular location: Type I membrane protein
  • Protein domains:

                   

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)