TNFRSF6 / FAS

                                                          (Tumor necrosis factor receptor superfamily, member 6)

  • Alias                                 (According to NCBI)

 
  • APO-1
  • APT1
  • CD95
  • FAS
  • FAS1
  • FASTM
  • APO-1 cell surface antigen
  • Fas antigen
  • apoptosis (APO-1) antigen 1
  • apoptosis antigen 1
  • tumor necrosis factor receptor superfamily, member 6
  • Tumor necrosis factor receptor superfamily member 6 precursor (FASL receptor) (Apoptosis-mediating surface antigen FAS) (Apo-1 antigen) (CD95)

  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.
  • Location: 10q24.1
  • Orientation: Plus strand
  • Size: 25,254 bases
  • 9 Exons
  • DNA Sequence:NT_030059

  • CGH (10q24.1): Losses (%) -9.5   Gain (%)  1.7  
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:335 amino acids; 37732 Da
  • Catalytic activity:
  • Sub cellular location: Type I membrane protein (isoform 1); Secreted (isoforms 2 to 6)
  • Protein domains:

                                                       
  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)