TNFSF6

                                                                 (Tumor necrosis factor (ligand) superfamily, member 6)

  • Alias                                 (According to NCBI)

 
  • APT1LG1 
  • CD178 
  • CD95L
  • FASLG
  • CD95 ligand
  • apoptosis (APO-1) antigen ligand 1
  • tumor necrosis factor (ligand) superfamily, member 6
  • Tumor necrosis factor ligand superfamily member 6 (FAS antigen ligand) (Apoptosis antigen ligand)
    (APTL) (CD178 antigen)

  • Apoptosis antigen ligand 1 is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with its ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in TNFSF6 may be related to some cases of systemic lupus erythematosus (SLE)
  • Location:1q23
  • Orientation: Plus strand
  • Size: 7,828 bases
  • 4 Exons
  • DNA Sequence: NT_004487

  • CGH (1q23): Losses (%) -1.1   Gain (%)  8.9  

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 281 amino acids; 31485 Da
  • Catalytic activity:
  • Sub cellular location: Type II membrane protein. May be released into the extracellular fluid,
    probably by cleavage form the cell surface.
  • Protein domains:
     

              

  • Pathways and interactions (According to BioCarta, DIP)
  • Clinical                            (According to OMIM, PubMed)