TNR

(Tenascin R (restrictin, janusin))

 

  • Alias                                 (According to NCBI)

 
  • Tenascin R (restrictin, janusin)
  • Tenascin-R (Restrictin)
  • Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]
  • Location:1q24
  • Orientation: minus strand
  • Size: 83997 bp
  • 21  exons
  • DNA sequence (Human):  NC_000001 

 

  • CGH (1q24): Losses (%) -1.1   Gain (%)  9.4  
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • HGMD:
  • SNPs: TNR
  • m-RNA                           (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_003285

  • Size: 4716 bp

  • cDNA libraries: TNR
  • Size:1358 amino acids; 149547 Da
  • Catalytic activity:

  • Subcellular location: Secreted; extracellular matrix

  • Protein domains

                                
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:
  • Clinical                            (According to OMIM, PubMed)