TPM2

(TROPOMYOSIN 2 (Beta))

 

  • Alias                                 (According to NCBI)

 
  • AMCD1
  • DA1 
  • HGNC:454
  • TMSB 
  • arthrogryposis multiplex congenital, distal, type 1 
  • tropomyosin 2 (beta) 
  • Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).
  • This protein belongs to topomyosin family and play a central role in association with the troponin complex, in the calcium dependent regulation of vertebrate striated. Binds to actin filaments in muscle and nonmuscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated
    muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In nonmuscle cells is implicated in stabilizing cytoskeleton actin filaments. The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven- residues periodicity
  • Location: 9p13.2-p13.1
  • Orientation: minus strand
  • Size: 8,063 bp
  • 9 exons
  • DNA sequence (Human): NC_000009.

       

  • CGH (9p13.2 - 13.1): Losses (%) -13.4   Gain (%)  8.9  

  • Mutations and SNPs  (According to HGMD and SNP)

 

 
  • m-RNA                           (According to NCBI and CGAP)

 

·         Subcellular location:

·         Protein domains

   

Protein sequence (Human): P07951

Homologous genes: TPM2

2D PAGE: P07951

3D Structure:

PTM: TPM2

 
  • Pathways and interactions (According to BioCarta, DIP)

 

 
Clinical                            (According to OMIM, PubMed)