WNT14

Wingless-type MMTV integration site family, member 14

 

  • Alias                                 (According to NCBI)

 
  • WNT14
  • wingless-type MMTV integration site family, member 14
  • wingless-type MMTV integration site family, member 9A
  • Wnt-9a protein precursor (Wnt-14).

  • The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.
  • Location:1q42
  • Orientation: minus strand
  • Size:  26903 bp
  • 4  exons
  • DNA sequence (Human): NC_000001


  • CGH (1q42): Losses (%) -0.6   Gain (%)  11.7  

  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 

  • mRNA sequence (Human): NM_003395

  • Size: 1631 bp

  • cDNA libraries: WNT14
  • Size:365 amino acids; 40320 Da
  • Catalytic activity:

  • Subcellular location: Possibly secreted and associates with the extracellular matrix.

  • Protein domains


 

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  • Protein interactions:

  • Clinical                            (According to OMIM, PubMed)