• Alias                                 (According to NCBI)

• GUD,
• WAGR,
• WIT-2,
• WT33

• Description   

  (According to SwissProt)

• Potential role in transcriptional regulation. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'.

• Chromosomal location

  (According to NCBI, CGH: progenetix)

• Location: 11p13
• Size: 47763 bp
• exons: 9 10 9 10
• DNA sequence (Human): NC_000011.8

• CGH (11p13):  Losses (%) -14.5   Gain (%)  4.5  

• Mutations and SNPs (According to HGMD and SNP)

• HGMD : WT1
• SNPs: 7490

• m-RNA                       (According to NCBI and CGAP)

• mRNA sequence (Human):

• Trascript variantA: NM_000378.3

• Trascript variantB: NM_024424.2

• Trascript variantC: NM_024425.2

• Trascript variantD: NM_024426.3

• Size:

• Trascript variantA: 2969 bp

• Trascript variantB: 3020 bp

• Trascript variantC: 2978 bp

• Trascript variantD: 3029 bp

• cDNA libraries:

• Protein                        (According to SwissProt, Swiss2D, PDB, dbPTM)

• Size: 449 amino acids: 49188 Da
• Catalytic activity:

• Subcellular location: Nucleus.

• Protein domains

     

• Protein sequence (Human): P19544

• Homologous genes:  11536

• 2D PAGE: WT1

• 3D Structure:   2PRT 2JPA 2JP9

• PTM: WT1

 

• Pathways and interactions (According to BioCarta, IntAct)

• Pathway:

          Chaperones modulate interferon signaling pathway

          Overview of telomerase component gene hTert Transcriptional Regulation

• Protein interactions:

• Tissue

  (According to GeneNote, PubMed, HPA)

• Tissue expression: PubMed Reference
• Human Protein Atlas (HPA): CAB000327

• Clinical                            (According to OMIM, PubMed)

• OMIM : 607102
• PubMed:    Early detection      Diagnosis         Prognosis        Therapy