XRCC1

                                                   (X-ray repair complementing defective repair in Chinese hamster cells 1)

  • Alias                                 (According to NCBI)

 
  • RCC
  • DNA repair protein XRCC1
  • X-ray repair complementing defective repair in Chinese hamster cells 1
  • X-ray-repair, complementing defective, repair in Chinese hamster
  • DNA-repair protein XRCC1.

  • The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
  • Location: 19q13.2
  • Orientation: Minus strand
  • Size: 32,251 bases
  • 17 Exons
  • DNA Sequence: NT_011109

  • CGH (19q13.2): Losses (%) -2.8   Gain (%)  8.9 

 
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size:633 amino acids; 69525 Da
  • Catalytic activity:
  • Sub cellular location: Nuclear
  • Protein domains:

                  

  • Pathways and interactions (According to BioCarta, DIP)
  • Pathways:
  • Interactions:
  • Clinical                            (According to OMIM, PubMed)