ZAP70

 (Part of the Receptor of T-cells)

 

  • Alias                                 (According to NCBI)

 
  • SRK
  • STD 
  • TZK
  • ZAP-70
  • syk-related tyrosine kinase
  • truncated ZAP kinase 
  • zeta-chain (TCR) associated protein kinase (70 kD)
  • zeta-chain (TCR) associated protein kinase 70kDa
  • zeta-chain associated protein kinase 70kDa
  • zeta-chain associated protein kinase, 70kD
  • Tyrosine-protein kinase ZAP-70 (EC 2.7.1.112) (70 kDa zeta-associated protein) (Syk-related
    tyrosine kinase). 
  •  
  • Location: 2q12
  • Orientation: plus strand
  • Size: 26,294 bp
  • 15 exons
  • DNA sequence (Human):NC_000002


  • CGH (2q12): Losses (%) -2.2   Gain (%)  4.5  
  • Mutations and SNPs  (According to HGMD and SNP)

 
  • m-RNA                           (According to NCBI and CGAP)

 
  • Size: 619 amino acids; 69872 Da  
  • Catalytic activity: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

  • Subcellular location:

  • Protein domains

 
  • Pathways and interactions (According to BioCarta, DIP)

  • Pathway:

  1. Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

  2. Lck and Fyn tyrosine kinases in initiation of TCR Activation

  3. T Cell Receptor Signaling Pathway          

  • Protein interactions:

 
  • Clinical                            (According to OMIM, PubMed)