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Principal Investigator

Dr. Neelam V Shirsat

Principal Investigator

RESEARCH

Brain tumours are one of the leading causes of cancer related deaths. Glioblastoma (GBM) and Medulloblastoma are two high grade malignant brain tumours that differ strikingly in their clinical behaviour and underlying biology. they have been using high throughput genomic technologies to identify genetic alterations and delineate their role in pathogenesis of medulloblastomas. While the genetic alterations in GBMs are largely understood, their complexity accompanied by the intrinsic resistance and invasive potential of GBMs poses enormous challenge to identification of therapeutic targets in GBMs. They have been investigating the molecular basis of the intrinsic resistance of GBM cells to cell death. 

Ongoing Research Projects

  • project1

    Molecular sub-groups of medulloblastomas and correlation with clinical characteris…

    Genome wide expression profiling studies including our own study has demonstrated that medulloblastoma is compri… more

  • project1

    Differential microRNA expression in molecular subgroups of medulloblastomas: role…

    We have carried out microRNA profiling of medulloblastomas in parallel with genome-wide expression profiling of… more

  • project1

    MiR-224 expression increases radiation sensitivity of glioblastoma cells

    Glioblastoma (GBM) is the most common and highly aggressive primary malignant brain tumor. The intrinsic resista… more

  • project1

    MiR-148a, a microRNA upregulated in the WNT subgroup tumors, inhibits invasion and…

    "Medulloblastoma, a common pediatric malignant brain tumor consists of four molecular subgroups viz. WNT, SHH, G… more

  • project1

    MiR-206, a Cerebellum Enriched miRNA Is Downregulated in All Medulloblastoma Subgr…

    Medulloblastoma is the most common and a highly malignant pediatric brain tumor located in the cerebellar region… more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. Neelam V Shirsat

KS-149, Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India.+91 (022) 2740 5000/ 6873 5000 Extn-5016 nshirsat@actrec.gov.in Lab Website
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