Inner Banner

Principal Investigator

Dr. S V Chiplunkar

Principal Investigator

Research Interests

Understanding the immunobiology of γδ T cells with reference to anti–tumor immunity Mechanism of immune dysfunction in patients –Role of CD3–zeta chain and Cox Clonality of TCR and Ig genes in Leukemias and Lymphomas Crosstalk of NKT cells and Regulatory T cells Biomarkers for cancer diagnosis and prognosis Immunotherapy of cancer

RESEARCH

The focus of lab is on understanding the immune scenario and reasons for immune dysfunctions in patients with cancer. The lab is also interested in studying the role of hematopoietic and mesenchymal stem cells for management of hematological neoplasms, tissue regeneration and repair.

Ongoing Research Projects

  • project1

    Activation and death of lymphocytes in patients with oral cancer

    γδ T cells play an important role as anti-tumor effector cells. However, their expansion is self-limiting. We in… more

  • project1

    Potential of lymphocytes stimulated with non-peptidic antigens for immunotherapy o…

    We are currently interested in analyzing the non-peptidic ligands recognized by γδ T cells on tumor cells. Our s… more

  • project1

    Toll-like receptors and antitumor immunity: Role of lymphocytes

    The present project aims at understanding the role of Toll like receptors (TLRs) and regulatory T cells in modul… more

  • project1

    Down regulation of CD3 zeta chain expressionin T cells of oral

     Immunosuppression appears to be more frequent and more profound in patients with head and neck cancer. The immu… more

  • project1

    Role of alkylamines in priming lymphocytes for antitumor effector functions

    Alkylamines are the group of non peptidic molecules, which are capable of stimulating Vγ9/Vδ2 T cells. These alk… more

  • project1

    Analysis of clonal TCR and gene rearrangements in T-ALL:Significance in diagnosis…

    T-cell Acute Lymphoblastic Leukemia (T-ALL) is a clonal lymphoid malignancy. The present project aimed at determ… more

  • project1

    Role of cycloxygenases and its inhibitors in lymphocyte activation and in restorin…

    The present study focuses on understanding the reasons for immune dysfunction in lung cancer (LC) patients and u… more

Lab Members

PUBLICATIONS

Contact

Office Contact

Dr. S V Chiplunkar

Advance Centre for Treatment Research & Education in Cancer, Tata Memorial Centre, (ACTREC), Plot No. 1 & 2, Sector 22, Kharghar, Navi Mumbai-410210. Maharashtra India. +91 (022) 2740 5000/ 6873 5000 Extn-5032 schiplunkar@actrec.gov.in Lab Website

Media Gallery

Back to Top